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ea0029oc10.4 | Pituitary Clinical 2 | ICEECE2012

Higher glucocorticoid supplementation doses are associated with increased overall mortality in patients with non-functioning pituitary adenoma

Zueger T. , Kirchner P. , Herren C. , Allemann S. , Fischli S. , Zwahlen M. , Christ E. , Stettler C.

Introduction: Current treatment guidelines for patients with insufficiency of the hypothalamic pituitary adrenal (HPA) axis recommend weight adjusted glucocorticoid supplementation doses to minimize risk of negative side effects (e.g. osteoporosis etc).However, little is known on a potential dose-dependent effect of glucocorticoid supplementation on overall mortality in patients with pituitary disease. Non-functioning pituitary adenoma (NFPA) is one of t...

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ea0029p1415 | Pituitary Clinical | ICEECE2012

The effect of GH replacement therapy on exercise capacity, fat mass, ectopic lipids intramyocellular and intrahepatocellular lipids and insulin resistance in hypopituitary patients with GH deficiency

Egger A , Allemann S , Stettler C , Diem P , Buehler T , Boesch C , Christ E

Introduction: Increased levels of ectopic lipids (IMCL and IHCL) have been related to insulin resistance. Aerobic exercise affects IMCL. GHRT is known to increase exercise capacity, insulin resistance and decrease fat mass. The effect of GHRT on ectopic lipids is not known.Methods: Ten patients with GHD and ten sedentary control subjects (CS; matched for gender, age, BMI and waist) were recruited. VO2max was assessed using an exercise test on ...

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Endocrine Abstracts

Higher glucocorticoid supplementation doses are associated with increased overall mortality in patients with non-functioning pituitary adenoma

The effect of GH replacement therapy on exercise capacity, fat mass, ectopic lipids intramyocellular and intrahepatocellular lipids and insulin resistance in hypopituitary patients with GH deficiency

BiosciAbstracts